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This collection of records assembled by John Willis Clark, documents the development of the former Botanic Garden in central Cambridge as the site - the New Museums site as it became known - for teaching and research in science subjects. Clark, who was Superintendent of the Museum of Zoology and Secretary of the Museums and Lecture Rooms Syndicate 1865-91, provided a contents list at the start of each volume. This has been transcribed in the descriptions below.

The archives comprise limited quantities of administrative material, including of the Computing Service. Much more significant are the surviving records of EDSAC and EDSAC 2 [Electronic Delay Storage Automatic Calculator], among the earliest electronic computers, developed in the late 1940s and 1950s.