Simon Boniface was a consultant neurophysiologist at Addenbrooke's Hospital, Cambridge, from 1985 until his death in 2005. He obtained a place at University College Hospital, London, where he was attracted to neuroscience as a career by the mentorship of Semir Zeki. Boniface obtained many prizes and graduated with honours.

After graduating, he undertook postgraduate training in medicine, ophthalmology and neurology, and settled on a career in clinical neurophysiology, which combined his academic and clinical skills. He obtained a prestigious MRC training fellowship based at the Radcliffe Infirmary, Oxford, and undertook an MD on the new and expanding topic of transcranial magnetic stimulation (TMS), making important contributions to the understanding of motor physiology in both normal and diseased states. This work was undertaken under the supervision of Kerry Mills.

In 1995, he was appointed to the first full-time position in clinical neurophysiology at Addenbrooke's Hospital. He continued his academic interests and forged strong collaborative links with members of the Wolfson Brain Imaging Centre. He published a string of important papers on neurophysiology, TMS and cerebral plasticity. In 2003 he co-edited the book 'Plasticity in the human nervous system - investigations with transcranial magnetic stimulation' with Ulf Ziemann, published by the Cambridge University Press, and played an active role in the Academy of Medical Sciences' report on neurorehabilitation. (from Munk's Roll, Vol. 11, p68, Royal College of Physicians)